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J Acupunct Meridian Stud. 2013 Feb;6(1):18-23. doi: 10.1016/j.jams.2012.07.019. Epub 2012 Aug 11.

Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats.

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1
Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. hosseinzadehh@mums.ac.ir

Abstract

Nigella sativa L. is used as a galactagogue in traditional medicine. Hence, the effects of aqueous and ethanolic extracts of N. sativa seeds on milk production in rats were evaluated. The measurement of milk production was by measuring pup weight during suckling period. The intraperitoneal LD(50) values of aqueous and ethanolic extracts of N. sativa were 4.23 and 4.9 g/kg, respectively. The aqueous (0.5 g/kg) and ethanolic extracts (1 g/kg) increased milk production significantly (p < 0.001), producing about 31.3% and 37.6% more milk than control, respectively. During the study period, the pups gained weight with the aqueous (0.5 g/kg, p < 0.01) and ethanolic extracts (1 g/kg, p < 0.05). It is concluded that aqueous and ethanolic extracts of N. sativa can stimulate milk production in rats.

PMID:
23433051
DOI:
10.1016/j.jams.2012.07.019
[Indexed for MEDLINE]
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