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Am J Transplant. 2013 May;13(5):1343-9. doi: 10.1111/ajt.12178. Epub 2013 Feb 22.

Bilateral transfemoral lower extremity transplantation: result at 1 year.

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Clinica Cavadas, Reconstructive Surgery Unit, Universitary Hospital La Fe, Valencia, Spain.


Upper limb transplantation has become a treatment option for upper limb amputees with good midterm results. Lower extremity transplantation has never been considered for fear of poor results. The authors present a bilateral transfemoral transplantation of lower extremities performed to a 22-year patient at 12 months of follow-up. The donor was a full HLA-mismatched female multiorgan donor. CMV status was D-/R-. A primary CMV infection coincident with an acute rejection occurred at 3 months and responded to treatment. At 1 year, the Tinel's sign is at malleolar level, there is active knee extension and active plantar flexion of the foot. The patient is walking between parallel bars. Further substantial improvements are expected with longer rehabilitation and follow-up.

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