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Cancer Invest. 2013 Mar;31(3):183-8. doi: 10.3109/07357907.2013.767342. Epub 2013 Feb 22.

Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer.

Author information

1
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

BACKGROUND:

This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer.

METHODS:

Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors.

RESULTS:

Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6).

CONCLUSIONS:

Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.

PMID:
23432821
PMCID:
PMC4596242
DOI:
10.3109/07357907.2013.767342
[Indexed for MEDLINE]
Free PMC Article
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