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Brain Pathol. 2013 Mar;23(2):206-9. doi: 10.1111/bpa.12020.

Emerging insights into the ependymoma epigenome.

Author information

1
Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. stephen.mack@mail.utoronto.ca

Abstract

Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients.

PMID:
23432646
DOI:
10.1111/bpa.12020
[Indexed for MEDLINE]
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