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Genes Dev. 2013 Feb 15;27(4):355-71. doi: 10.1101/gad.210773.112.

The Hippo pathway: regulators and regulations.

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1
Department of Pharmacology, Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA.

Abstract

Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation. Recently, numerous upstream components involved in the Hippo pathway have been identified, such as cell polarity, mechanotransduction, and G-protein-coupled receptor (GPCR) signaling. Actin cytoskeleton or cellular tension appears to be the master mediator that integrates and transmits upstream signals to the core Hippo signaling cascade. Here, we review regulatory mechanisms of the Hippo pathway and discuss potential implications involved in different physiological and pathological conditions.

PMID:
23431053
PMCID:
PMC3589553
DOI:
10.1101/gad.210773.112
[Indexed for MEDLINE]
Free PMC Article
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