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J Biol Chem. 2013 Mar 29;288(13):8785-93. doi: 10.1074/jbc.R113.451211. Epub 2013 Feb 19.

Interstitial collagen catabolism.

Author information

  • 1Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA. gfields@tpims.org

Abstract

Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. Components of the mechanism of action for the collagenolytic enzyme MMP-1 have been defined experimentally, and insights into other collagenolytic mechanisms have been provided. Ancillary biomolecules may modulate the action of collagenolytic enzymes.

PMID:
23430258
PMCID:
PMC3610953
DOI:
10.1074/jbc.R113.451211
[PubMed - indexed for MEDLINE]
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