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J Med Microbiol. 2013 May;62(Pt 5):663-76. doi: 10.1099/jmm.0.053983-0. Epub 2013 Feb 21.

Type VI secretion system regulation as a consequence of evolutionary pressure.

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Department of Medical Microbiology and Immunology, 6-22 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.


The type VI secretion system (T6SS) is a mechanism evolved by Gram-negative bacteria to negotiate interactions with eukaryotic and prokaryotic competitors. T6SSs are encoded by a diverse array of bacteria and include plant, animal, human and fish pathogens, as well as environmental isolates. As such, the regulatory mechanisms governing T6SS gene expression vary widely from species to species, and even from strain to strain within a given species. This review concentrates on the four bacterial genera that the majority of recent T6SS regulatory studies have been focused on: Vibrio, Pseudomonas, Burkholderia and Edwardsiella.

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