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Org Biomol Chem. 2013 Apr 28;11(16):2586-96. doi: 10.1039/c3ob27209e.

Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation.

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1
Departamento de Q. Orgánica, Facultad de Ciencia, Instituto de Biotecnologia, Universidad de Granada, Granada, 18071 Spain.

Abstract

The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene-sugar, ferrocene-cyclodextrin, ferrocene-peptide and ferrocene-protein conjugates).

PMID:
23429475
DOI:
10.1039/c3ob27209e
[Indexed for MEDLINE]
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