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J Bioinform Comput Biol. 2013 Feb;11(1):1340007. doi: 10.1142/S0219720013400076. Epub 2013 Jan 16.

Criteria for an updated classification of human transcription factor DNA-binding domains.

Author information

1
Department of Bioinformatics, University Medical Center Göttingen, Goldschmidtstr. 1, Göttingen, D-37077, Germany. edgar.wingender@bioinf.med.uni-goettingen.de

Abstract

By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.

PMID:
23427989
DOI:
10.1142/S0219720013400076
[Indexed for MEDLINE]

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