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Breast Cancer Res. 2013 Feb 18;15(1):303. doi: 10.1186/bcr3360.

A functional link between FOXA1 and breast cancer SNPs.

Abstract

Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor.

PMID:
23427833
PMCID:
PMC3745646
DOI:
10.1186/bcr3360
[Indexed for MEDLINE]
Free PMC Article

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