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Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a012161. doi: 10.1101/cshperspect.a012161.

Ethanol effects on N-methyl-D-aspartate receptors in the bed nucleus of the stria terminalis.

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1
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.

Abstract

The extended amygdala is a series of interconnected, embryologically similar series of nuclei in the brain that are thought to play key roles in aspects of alcohol dependence, specifically in stress-induced increases in alcohol-seeking behaviors. Plasticity of excitatory transmission in these and other brain regions is currently an intense area of scrutiny as a mechanism underlying aspects of addiction. N-methyl-D-aspartate (NMDA) receptors (NMDARs) play a critical role in plasticity at excitatory synapses and have been identified as major molecular targets of ethanol. Thus, this article will explore alcohol and NMDAR interactions first at a general level and then focusing within the extended amygdala, in particular on the bed nucleus of the stria terminalis (BNST).

PMID:
23426579
PMCID:
PMC3684001
DOI:
10.1101/cshperspect.a012161
[Indexed for MEDLINE]
Free PMC Article
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