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J Clin Gastroenterol. 2013 Jul;47(6):e55-9. doi: 10.1097/MCG.0b013e31827b9325.

Osteopontin promoter polymorphisms are associated with susceptibility to gastric cancer.

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1
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.

Abstract

GOALS:

To evaluate the significance of osteopontin (OPN) genotypes in the susceptibility to gastric cancer.

BACKGROUND:

The expression of OPN has been correlated with development, invasiveness, metastasis, and survival of gastric cancer, but the role of polymorphisms in the OPN promoter has not been investigated.

STUDY:

We enrolled 146 gastric cancer patients and 128 controls. DNA was extracted from peripheral blood leucocytes. Single-nucleotide polymorphisms (SNPs) in the OPN promoter (-66, -156, -443, -616, -1748, and -1776) were analyzed by pyrosequencing and direct sequencing methods. Logistic regression analyses were used to evaluate the associations between SNPs and development of gastric cancer.

RESULTS:

SNP -443 C/C and -616 T/T of the OPN promoter were significantly associated with gastric cancer [odds ratio (OR)=2.88; 95% confidence interval (CI), 1.16-7.12 and OR=1.95; 95% CI, 1.35-2.82, respectively]. Analysis of the combined effect of OPN promoter SNPs revealed that the combination of SNP -443 (T/C or C/C) and SNP -616 (T/T or T/G) had the most significant association with gastric cancer (OR=3.95; 95% CI, 1.58-9.90).

CONCLUSIONS:

Our results suggest that polymorphisms in the OPN promoter are associated with the development of gastric cancer, and the combination of SNP -443 (T/C or C/C) and -616 (T/T or T/G) most significantly increases susceptibility to gastric cancer.

PMID:
23426449
DOI:
10.1097/MCG.0b013e31827b9325
[Indexed for MEDLINE]
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