Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurol. 2013 Apr;26(2):111-21. doi: 10.1097/WCO.0b013e32835f19c3.

What have we learned from recent twin studies about the etiology of neurodevelopmental disorders?

Author information

1
Complex Trait Genetics, Departmentof Functional Genomics, VU University Amsterdam, De Boelelaan 1085, Amsterdam,The Netherlands. d.posthuma@vu.nl

Abstract

PURPOSE OF REVIEW:

The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs.

RECENT FINDINGS:

Recent twin studies have confirmed that NDDs show moderate-to-high heritability, and that from an etiological viewpoint both autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are best regarded as the extremes on a continuous liability distribution. Both ASD and ADHD show high heritability in childhood and a substantial drop in heritability in adulthood, which is likely explained by the use of different assessment strategies in childhood versus adulthood, or by a complex mechanism of gene-by-environment interaction. NDDs show substantial comorbidity among each other, and with other mental health problems, which is partly because of a shared genetic etiology between different disorders.

SUMMARY:

The findings of twin studies implicate substantial heritability of NDDs, and warrant large-scale molecular genetic studies for such traits.

PMID:
23426380
DOI:
10.1097/WCO.0b013e32835f19c3
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center