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J Pediatr Hematol Oncol. 2013 Apr;35(3):e130-3. doi: 10.1097/MPH.0b013e3182826656.

Pediatric extranodal marginal zone B-cell lymphoma presenting as amyloidosis in minor salivary glands: a case report and review of the literature.

Author information

1
Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109-1078, USA.

Abstract

We report an unusual case of an extranodal marginal zone B-cell lymphoma (EMZL) arising in the labial minor salivary gland in an immunocompetent 11-year-old boy. The initial histopathologic review favored localized amyloidosis. However, further evaluation supported the diagnosis of low-grade B-cell lymphoma with plasmacytic differentiation, surrounded by deposits of AL κ-type amyloid. Clinical management consisted of excision with no recurrence at 1-year follow-up. This case demonstrates that a diagnosis of lymphoma must be considered in cases of amyloidosis associated with minor salivary gland involvement, even in children. In addition, we provide a literature review of extranodal marginal zone B-cell lymphoma arising in salivary glands.

PMID:
23425998
DOI:
10.1097/MPH.0b013e3182826656
[Indexed for MEDLINE]

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