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Nature. 1990 May 31;345(6274):449-52.

Presentation of viral antigen controlled by a gene in the major histocompatibility complex.

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Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.


We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6.

[Indexed for MEDLINE]

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