Format

Send to

Choose Destination
See comment in PubMed Commons below
Lab Anim (NY). 2013 Mar;42(3):86-91. doi: 10.1038/laban.160.

Lipopolysaccharide-induced inflammation of bronchi and emphysematous changes of pulmonary parenchyma in miniature pigs (Sus scrofa domestica).

Author information

1
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China.

Abstract

Lipopolysaccharide (LPS) is widely used to induce chronic obstructive pulmonary disease (COPD) in animal models. Rodents are most commonly used to model COPD, but their substantial anatomic and physiological differences from humans present a challenge in the research of COPD pathogenesis. The authors induced COPD in miniature pigs by intratracheal administration of LPS solution. They carried out bronchoalveolar lavage (BAL) and collected the fluid for analyses of white blood cells, cytokines and proteases and obtained lung tissues for histological assessment. Intratracheal administration of LPS caused bronchitis, obstruction of distal bronchi and damage of pulmonary alveoli, as well as increases in white blood cell counts and expression levels of cytokines and proteases. These results are consistent with the presentation of COPD in humans, making LPS administration in miniature pigs a valuable animal model for the research of pathogenesis and treatment of COPD.

PMID:
23423297
DOI:
10.1038/laban.160
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center