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Nat Commun. 2013;4:1503. doi: 10.1038/ncomms2529.

A synthetic nanomaterial for virus recognition produced by surface imprinting.

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School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, GrĂ¼ndenstrasse 40, Muttenz CH-4132, Switzerland.


Major stumbling blocks in the production of fully synthetic materials designed to feature virus recognition properties are that the target is large and its self-assembled architecture is fragile. Here we describe a synthetic strategy to produce organic/inorganic nanoparticulate hybrids that recognize non-enveloped icosahedral viruses in water at concentrations down to the picomolar range. We demonstrate that these systems bind a virus that, in turn, acts as a template during the nanomaterial synthesis. These virus imprinted particles then display remarkable selectivity and affinity. The reported method, which is based on surface imprinting using silica nanoparticles that act as a carrier material and organosilanes serving as biomimetic building blocks, goes beyond simple shape imprinting. We demonstrate the formation of a chemical imprint, comparable to the formation of biosilica, due to the template effect of the virion surface on the synthesis of the recognition material.

[Indexed for MEDLINE]

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