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Macromol Biosci. 2013 May;13(5):551-61. doi: 10.1002/mabi.201200471. Epub 2013 Feb 18.

Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs.

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1
Department of Orthopaedics, University Medical Center, Utrecht, The Netherlands.

Abstract

Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.

PMID:
23420700
DOI:
10.1002/mabi.201200471
[Indexed for MEDLINE]

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