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Cancer Lett. 2013 Jul 10;335(1):214-8. doi: 10.1016/j.canlet.2013.02.017. Epub 2013 Feb 16.

Statin therapy is not associated with prostate cancer recurrence among patients who underwent radiation therapy.

Author information

1
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA. chun.r.chao@kp.org

Abstract

We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California health plan was followed for 5 years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio=0.99 (0.70-1.39), 0.87 (0.62-1.22) and 0.78 (0.55-1.09), respectively] in multivariable Cox models. No clear dose-response relationship was observed for average daily statin dose or duration of statin use. Our findings do not support a preventive benefit of statins in prostate cancer recurrence after radiotherapy.

PMID:
23419526
DOI:
10.1016/j.canlet.2013.02.017
[Indexed for MEDLINE]

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