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Cancer Lett. 2013 Jul 10;335(1):214-8. doi: 10.1016/j.canlet.2013.02.017. Epub 2013 Feb 16.

Statin therapy is not associated with prostate cancer recurrence among patients who underwent radiation therapy.

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Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA.


We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California health plan was followed for 5 years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio=0.99 (0.70-1.39), 0.87 (0.62-1.22) and 0.78 (0.55-1.09), respectively] in multivariable Cox models. No clear dose-response relationship was observed for average daily statin dose or duration of statin use. Our findings do not support a preventive benefit of statins in prostate cancer recurrence after radiotherapy.

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