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Cancer Lett. 2013 Jul 10;335(1):201-4. doi: 10.1016/j.canlet.2013.02.019. Epub 2013 Feb 16.

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth.

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1
Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.

Abstract

Exosomes are 30-150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor.

PMID:
23419525
PMCID:
PMC3665755
DOI:
10.1016/j.canlet.2013.02.019
[Indexed for MEDLINE]
Free PMC Article
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