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Drug Metabol Drug Interact. 2013;28(1):31-47. doi: 10.1515/dmdi-2012-0036.

Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds.

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1
Department of Applied Chemistry, BBA University, Lucknow, Uttar Pradesh, India.

Abstract

BACKGROUND:

Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.

METHODS:

In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.

RESULTS AND CONCLUSIONS:

Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.

PMID:
23417104
DOI:
10.1515/dmdi-2012-0036
[Indexed for MEDLINE]
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