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Biochim Biophys Acta. 2013 Aug;1829(8):884-93. doi: 10.1016/j.bbagrm.2013.02.002. Epub 2013 Feb 15.

DEAD-box helicases as integrators of RNA, nucleotide and protein binding.

Author information

1
Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.

Abstract

DEAD-box helicases perform diverse cellular functions in virtually all steps of RNA metabolism from Bacteria to Humans. Although DEAD-box helicases share a highly conserved core domain, the enzymes catalyze a wide range of biochemical reactions. In addition to the well established RNA unwinding and corresponding ATPase activities, DEAD-box helicases promote duplex formation and displace proteins from RNA. They can also function as assembly platforms for larger ribonucleoprotein complexes, and as metabolite sensors. This review aims to provide a perspective on the diverse biochemical features of DEAD-box helicases and connections to structural information. We discuss these data in the context of a model that views the enzymes as integrators of RNA, nucleotide, and protein binding. This article is part of a Special Issue entitled: The Biology of RNA helicases - Modulation for life.

PMID:
23416748
PMCID:
PMC3661757
DOI:
10.1016/j.bbagrm.2013.02.002
[Indexed for MEDLINE]
Free PMC Article

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