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Nat Immunol. 2013 Apr;14(4):346-55. doi: 10.1038/ni.2535. Epub 2013 Feb 17.

OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.

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1
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

Erratum in

  • Nat Immunol. 2013 Apr;14(4):355.
  • Nat Immunol. 2013 Aug;14(8):877.

Abstract

The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory responses. Here we found that OASL1 inhibited translation of IRF7, the master transcription factor for type I interferon, and thus negatively regulated the robust production of type I interferon during viral infection. OASL1 inhibited the translation of IRF7 mRNA by binding to the 5' untranslated region (UTR) of IRF7 and possibly by inhibiting scanning of the 43S preinitiation complex along the message. Oasl1-/- mice were resistant to viral infection because of the greater abundance of type I interferon, which suggests that OASL1 could be a potential therapeutic target for boosting the production of type I interferon during viral infection.

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PMID:
23416614
DOI:
10.1038/ni.2535
[Indexed for MEDLINE]
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