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Fertil Steril. 2013 Mar 15;99(4):998-1007. doi: 10.1016/j.fertnstert.2013.01.111. Epub 2013 Feb 15.

The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility.

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Scott Department of Urology, Department of Molecular and Cellular Biology, The Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.


Although male factors account for approximately 50% of all infertility, the mechanisms underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses to predict male reproductive potential and chart treatment success. Even when invasive procedures are performed, the causes of male factor infertility frequently remain elusive. Recently, the advent of new technologies has spurred the search for novel male infertility biomarkers, and the detection of genes, proteins, or metabolites unique to the infertile male holds much promise. The concept that a cost-effective, noninvasive, and accurate set of biomarkers can be identified to diagnose male factor infertility is tantalizing. This review focuses on the various methodologies used in the discovery of novel biomarkers along with their findings. Specific attention is paid to recent advances in the fields of genetics, proteomics, and metabolomics.

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