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Fertil Steril. 2013 May;99(6):1674-80. doi: 10.1016/j.fertnstert.2013.01.108. Epub 2013 Feb 14.

Association of methionine synthase and thymidylate synthase genetic polymorphisms with idiopathic recurrent pregnancy loss.

Author information

1
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea.

Abstract

OBJECTIVE:

To investigate the association between one-carbon metabolism and recurrent pregnancy loss (RPL). One-carbon metabolism is important for maintaining pregnancy, and the enzymes codified by these genes are relevant to this metabolic pathway.

DESIGN:

Case-control study.

SETTING:

An urban university-based hospital in South Korea.

PATIENT(S):

A cohort of 353 RPL patients (3.09 ± 1.65 pregnancy losses) and 226 control subjects.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Genotyping was assessed by polymerase chain reaction-restriction fragment length polymorphism assay. We examined polymorphisms in four genes: methionine synthase (MTR); methionine synthase reductase (MTRR); methylenetetrahydrofolate dehydrogenase 1 (MTHFD1); and thymidylate synthase (TS).

RESULT(S):

The MTR 2756AA polymorphism was associated with RPL. Gene-gene interaction analysis revealed that the frequency of the MTR 2756A-TS 6-bp allele combination was significantly higher in RPL.

CONCLUSION(S):

Based on these results, we propose that the MTR 2756AA genotype and MTR 2756A-TS 6-bp allele combination are possible predisposing factors for RPL development in Korean women.

[Indexed for MEDLINE]

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