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Trends Parasitol. 2013 Mar;29(3):135-41. doi: 10.1016/j.pt.2013.01.003. Epub 2013 Feb 15.

Infection and treatment immunizations for successful parasite vaccines.

Author information

1
Institute for Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK. fmutapi@staffmail.ed.ac.uk

Abstract

Since the advent of techniques for the expression of recombinant peptide antigens, the availability of human vaccines for parasitic diseases has been 'imminent'. Yet vaccines based on recombinant proteins are still largely aspirations, not realities. It is now apparent that vaccine development needs additional knowledge about host protective immune response(s), antigen characteristics, and the delivery required to induce those responses. The most successful immune protection against parasites has been generated by infection and treatment, the induction of protective immunity by truncating the course of an infection with drug treatment. Here, we consider the characteristics of an effective, protective anti-parasite vaccine and propose a conceptual framework to aid parasite vaccine development using malaria and schistosomiasis as examples.

PMID:
23415733
PMCID:
PMC3884123
DOI:
10.1016/j.pt.2013.01.003
[Indexed for MEDLINE]
Free PMC Article
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