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Ultrasound Med Biol. 2013 Apr;39(4):611-9. doi: 10.1016/j.ultrasmedbio.2012.11.026. Epub 2013 Feb 13.

Non-invasive embolus trap using histotripsy-an acoustic parameter study.

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1
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Free-flowing particles in a blood vessel were observed to be attracted, trapped and eroded by a histotripsy bubble cloud. This phenomenon may be used to develop a non-invasive embolus trap (NET) to prevent embolization. This study investigates the effect of acoustic parameters on the trapping ability of the NET generated by a focused 1.063 MHz transducer. The maximum trapping velocity, defined by the maximum mean fluid velocity at which a 3-4 mm particle trapped in a 6 mm diameter vessel phantom, increased linearly with peak negative pressure (P-) and increased as the square root of pulse length and pulse repetition frequency (PRF). At 19.9 MPa P-, 1000 Hz PRF and 10 cycle pulse length, a 3 mm clot-mimicking particle could remain trapped under a background velocity of 9.7 cm/s. Clot fragments treated by NET resulted in debris particles <75 μm. These results will guide the appropriate selection of NET parameters.

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