Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Perinatol. 2013 Mar;40(1):79-91. doi: 10.1016/j.clp.2012.12.006. Epub 2013 Jan 17.

Lactoferrin and necrotizing enterocolitis.

Author information

1
Division of Neonatology, Women's and Children's Hospital, University of Missouri Health System, University of Missouri, Suite 206, 404 Keene Street, Columbia, MO 65201, USA. ShermanMP@health.missouri.edu

Abstract

Lactoferrin (LF) is a multifunctional protein and a member of the transferrin family. LF and lysozyme in breast milk kill bacteria. In the stomach, pepsin digests and releases a potent peptide antibiotic called lactoferricin from native LF. The antimicrobial characteristics of LF may facilitate a healthy intestinal microbiome. LF is the major whey in human milk; its highest concentration is in colostrum. This fact highlights early feeding of colostrum and also fresh mature milk as a way to prevent necrotizing enterocolitis.

PMID:
23415265
PMCID:
PMC3579561
DOI:
10.1016/j.clp.2012.12.006
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center