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Appl Radiat Isot. 2014 Jan;83 Pt B:128-36. doi: 10.1016/j.apradiso.2013.01.022. Epub 2013 Jan 20.

Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action.

Author information

1
Institute of Biophysics Brno, Academy of Sciences of the Czech Republic, Brno, Czech Republic; Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia; Institute of Chemical Technology Prague, Prague, Czech Republic.

Abstract

According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.

KEYWORDS:

DNA double-strand breaks (DSBs); Formation of chromosomal translocations; Gamma rays and proton beams; Higher-order chromatin structure and DSB repair; γH2AX foci

PMID:
23415104
DOI:
10.1016/j.apradiso.2013.01.022
[Indexed for MEDLINE]

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