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Expert Rev Vaccines. 2013 Feb;12(2):119-27. doi: 10.1586/erv.12.152.

Developments in virus-like particle-based vaccines for HIV.

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  • 1Department of Experimental Oncology, Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori 'Fond Pascale', Via Mariano Semmola 142, 80131 Napoli, Italy.

Abstract

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4(+) T-helper and CD8(+) cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.

PMID:
23414404
DOI:
10.1586/erv.12.152
[PubMed - indexed for MEDLINE]
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