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FEMS Microbiol Lett. 2013 May;342(1):30-6. doi: 10.1111/1574-6968.12104. Epub 2013 Mar 15.

Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme.

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1
ABBL, BARC, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA.

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall-binding domain is a potent agent against Staphylococcus aureus in four functional assays.

PMID:
23413880
PMCID:
PMC3690576
DOI:
10.1111/1574-6968.12104
[Indexed for MEDLINE]
Free PMC Article
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