Format

Send to

Choose Destination
See comment in PubMed Commons below
F1000 Biol Rep. 2013;5:4. doi: 10.3410/B5-4. Epub 2013 Feb 1.

PKM and the maintenance of memory.

Author information

1
Department of Integrative Biology and Physiology, University of California Los Angeles, CA, 90095 USA ; Department of Neurobiology and the Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, CA, 90095 USA ; Integrative Center for Learning and Memory, University of California Los Angeles, CA, 90095 USA.

Abstract

How can memories outlast the molecules from which they are made? Answers to this fundamental question have been slow coming but are now emerging. A novel kinase, an isoform of protein kinase C (PKC), PKMzeta, has been shown to be critical to the maintenance of some types of memory. Inhibiting the catalytic properties of this kinase can erase well-established memories without altering the ability of the erased synapse to be retrained. This article provides an overview of the literature linking PKMzeta to memory maintenance and identifies some of the controversial issues that surround the bold implications of the existing data. It concludes with a discussion of the future directions of this domain.

PMID:
23413372
PMCID:
PMC3564217
DOI:
10.3410/B5-4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Faculty of 1000 Icon for PubMed Central
    Loading ...
    Support Center