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Methods Mol Biol. 2013;973:197-212. doi: 10.1007/978-1-62703-281-0_13.

Array-CGH analysis of cutaneous anaplastic large cell lymphoma.

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Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.


This chapter describes a study in which the pattern of numerical chromosomal alterations in cutaneous anaplastic large cell lymphoma (C-ALCL) tumor samples was defined using array-based comparative genomic hybridization (CGH). First, the array-based CGH technique applied is outlined in detail. Next, its application in the analysis of C-ALCL tumor specimens is described. This approach resulted in the identification of highly recurrent chromosomal alterations in C-ALCL that include gain of 7q31 and loss on 6q16-6q21 and 13q34, each affecting 45% of the patients. The pattern characteristic of C-ALCL differs markedly from chromosomal alterations observed in other CTCL such as mycosis fungoides and S├ęzary syndrome and yielded several candidate genes with potential relevance in the pathogenesis of C-ALCL.

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