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Transcription. 2013 Mar-Apr;4(2):54-7. doi: 10.4161/trns.23191. Epub 2013 Feb 14.

When are the BET factors the most sensitive to bromodomain inhibitors?

Author information

1
INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot Grenoble, France. khochbin@ujf-grenoble.fr

Abstract

The recent publication of two detailed studies of mouse spermatogenesis, either after chemical inhibition of the BET bromodomains, or in the context of genetic alterations of one specific BET member, Brdt, provides the unique opportunity to assess the functional impact of BET bromodomain inhibitors.

KEYWORDS:

Brd2; Brd3; Brd4; Brdt; acetylation; cancer; chromatin; histone; infertility; pTEFb; spermatogenesis

PMID:
23412362
PMCID:
PMC3646053
DOI:
10.4161/trns.23191
[Indexed for MEDLINE]
Free PMC Article

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