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Transcription. 2013 Mar-Apr;4(2):62-6. doi: 10.4161/trns.23680. Epub 2013 Feb 14.

HIF proteins connect the RB-E2F factors to angiogenesis.

Author information

1
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Abstract

Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.

KEYWORDS:

E2F; HIF; RB; VEGF; angiogenesis; cancer; hypoxia

PMID:
23412359
PMCID:
PMC3646055
DOI:
10.4161/trns.23680
[Indexed for MEDLINE]
Free PMC Article

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