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Lab Chip. 2013 Apr 7;13(7):1243-6. doi: 10.1039/c3lc50104c.

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.

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1
Tecnológico de Monterrey at Monterrey, Centro de Biotecnología-FEMSA, Ave. Eugenio Garza-Sada 2501, Monterrey, N.L., México.

Abstract

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

PMID:
23412111
DOI:
10.1039/c3lc50104c
[Indexed for MEDLINE]
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