Send to

Choose Destination
Invest Ophthalmol Vis Sci. 2013 Mar 11;54(3):1797-804. doi: 10.1167/iovs.12-11191.

A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma.

Author information

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.



To evaluate prediagnostic markers of endothelial dysfunction and inflammatory processes in primary open-angle glaucoma (POAG).


Blood samples were collected from 1989 to 1990 in the nurses' health study (women) and from 1993 to 1995 in the health professionals follow-up study (men), and medical-record confirmed incident poag cases were identified (women: 229 cases and 455 controls; men: 116 cases and 228 controls). Controls were matched on cohort, age, race, ethnicity, cancer status, and date of blood collection. Plasma concentrations of ICAM-1, E-selectin, and soluble TNF receptor 2 (sTNF-R2), a marker related to TNF-α, were measured with ELISA assays. Cohort-specific multivariable conditional logistic regression model results were meta-analyzed.


We observed no associations with ICAM-1 or E-selectin. for sTNF-R2, the mean (SD) plasma levels (pg/ml) in cases and controls were 2888 (997) and 2993 (913), respectively, in women; and 2622 (664) and 2569 (688), respectively, in men. pooled multivariable results showed no relation between sTNF-R2 levels and POAG. however, compared with the lowest tertile of sTNF-R2, the highest tertile showed a significant decreased risk of POAG in women (multivariable odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.360.93; P(trend) = 0.03) but not in men (P(trend) = 0.21; P for heterogeneity by sex = 0.03). also, among women, the inverse association with sTNF-R2 was stronger with normal-tension glaucoma (ntg; maximum intraocular pressure 21 mm Hg at diagnosis): highest versus lowest tertile comparison OR = 0.29 (95% CI = 0.12-0.71; Ptrend = 0.007).


In women, but not in men, higher sTNF-R2 levels at 6 to 8 years before diagnosis were inversely associated with POAG, but more strongly for NTG.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center