Format

Send to

Choose Destination
See comment in PubMed Commons below
Intern Med. 2013;52(4):483-8. Epub 2013 Feb 15.

Central nervous system lymphoma initially diagnosed as tumefactive multiple sclerosis after brain biopsy.

Author information

1
Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan. yooe@saitama-med.ac.jp

Abstract

A 72-year-old man was admitted with left homonymous hemianopsia and hemiparesis. Magnetic resonance imaging revealed a heterogeneously enhanced lesion in the right parietal lobe. A brain biopsy showed acute demyelination without malignancy, which led to a diagnosis of tumefactive multiple sclerosis (MS). The patient received corticosteroid therapy and experienced clinical and radiological improvement. Six months later, new lesions appeared, and a second biopsy revealed proliferation of dysplastic lymphocytes. This led to a revised diagnosis of primary central nervous system lymphoma (PCNSL). Because PCNSL mimics MS both clinically and radiologically, PCNSL is difficult to diagnose. Performing repeated brain biopsies may therefore be required when PCNSL is strongly suspected.

PMID:
23411706
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
    Loading ...
    Support Center