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J Pharm Biomed Anal. 2013 Apr 15;77:94-9. doi: 10.1016/j.jpba.2013.01.016. Epub 2013 Jan 14.

Evaluating MISER chromatography for a rapid formulation screen.

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AstraZeneca Research and Development, Innovative Medicines, Department of Medicinal Chemistry, St-Laurent, QC, Canada.


MISER chromatography was evaluated to increase data processing speed for a rapid, miniaturized in vitro formulation screen. This approach permitted quick data interpretation by eliminating time-consuming steps such as integration, quantitation and report generation. Some flexibility in analytical methodology was lost due to limited instrument platforms capable of injecting multiple samples and acquiring all data in a single chromatogram. In our instrumental setup, an isocratic run was used to perform MISER chromatography, producing results comparable to our generic gradient methods while reducing processing times. This novel data format was easily interpreted and provides equivalent information to a formulation scientist as compared to traditional tabulated reports.

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