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Cancer Cell. 2013 Feb 11;23(2):133-5. doi: 10.1016/j.ccr.2013.01.019.

Molecular archeology: unearthing androgen-induced structural rearrangements in prostate cancer genomes.

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Centre for Integrative Biology, University of Trento, Povo, Trento, 38123, Italy.


In this issue of Cancer Cell, Weischenfeldt and colleagues report on the whole genome sequencing of 11 early-onset prostate cancers. Compared to elderly onset prostate cancer, these tumors demonstrate enrichment for androgen-driven structural rearrangements involving ETS family genes. This study confirms observations that prostate cancer manifests discrete genomic subclasses.

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