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Org Lett. 2013 Mar 1;15(5):1036-9. doi: 10.1021/ol303483t. Epub 2013 Feb 14.

Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation.

Author information

1
College of Science, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.

Abstract

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

PMID:
23410073
DOI:
10.1021/ol303483t
[Indexed for MEDLINE]

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