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Biomarkers. 2013 Mar;18(2):126-35. doi: 10.3109/1354750X.2012.751455.

Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer.

Author information

1
Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.

Abstract

OBJECTIVE:

The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.

MATERIALS AND METHODS:

We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.

RESULTS:

Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.

PMID:
23410046
DOI:
10.3109/1354750X.2012.751455
[Indexed for MEDLINE]

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