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Comb Chem High Throughput Screen. 2013 Jun 28;16(7):550-61.

Combinatorial synthesis of pyrazoloquinoline and pyrazoloacridine derivatives with high regioselectivity.

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1
School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu 221116, PR China.

Abstract

Three-component reaction of aldehyde, 1H-indazol-6-amine and 1,3-dicarbonyl compounds in EtOH under catalyst-free conditions, generates the corresponding pyrazolo[3,4-a]acridine, cyclopenta[b]pyrazolo[3,4-f]quinoline, indeno[1,2-b]pyrazolo[3,4-f]quinoline and benzo[h]pyrazolo[3,4-a]acridine derivatives in high yields and regioselectivity, respectively. The dicarbonyl compounds include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, 2H-indene- 1,3-dione and 2-hydroxynaphthalene-1,4-dione.

PMID:
23410044
[Indexed for MEDLINE]
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