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Obesity (Silver Spring). 2013 Sep;21(9):E415-20. doi: 10.1002/oby.20338.

Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.

Author information

1
Division of Endocrinology Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA.

Abstract

OBJECTIVE:

To investigate how long-term treatment with dexamethasone affects energy expenditure and adiposity in mice and whether this is influenced by feeding on a high-fat diet (HFD).

DESIGN AND METHODS:

Mice were placed on a HFD for 2 weeks and started on dexamethasone at 5 mg/kg every other day during the next 7 weeks.

RESULTS:

Treatment with dexamethasone increased body fat, an effect that was more pronounced in the animals kept on HFD; dexamethasone treatment also worsened liver steatosis caused by the HFD. At the same time, treatment with dexamethasone lowered the respiratory quotient in chow-fed animals and slowed nightly metabolic rate in the animals kept on HFD. In addition, the acute VO2 acceleration in response to β3 adrenergic-stimulation was significantly limited in the dexamethasone-treated animals, as a result of marked decrease in UCP-1 mRNA observed in the brown adipose tissue of these animals.

CONCLUSIONS:

Long-term treatment with dexamethasone in a mouse model of diet-induced obesity decreases brown adipose tissue thermogenesis and exaggerates adiposity and liver steatosis. © 2013 American Institute of Chemical Engineers AIChE J, 2013.

PMID:
23408649
PMCID:
PMC4451231
DOI:
10.1002/oby.20338
[Indexed for MEDLINE]
Free PMC Article
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