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Obesity (Silver Spring). 2013 Dec;21(12):2582-8. doi: 10.1002/oby.20321. Epub 2013 May 29.

Associations of leukocyte telomere length with body anthropometric indices and weight change in Chinese women.

Author information

1
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.

Abstract

OBJECTIVE:

This study evaluated associations of telomere length with various anthropometric indices of general and abdominal obesity, as well as weight change.

DESIGN AND METHODS:

The study included 2,912 Chinese women aged 40-70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative telomere length.

RESULTS:

Telomere length was inversely associated with body mass index (BMI), waist circumference, waist-to-height ratio, weight, and hip circumference (Ptrend = 0.005, 0.004, 0.004, 0.010, and 0.026, respectively), but not waist-to-hip ratio (Ptrend = 0.116) or height (Ptrend = 0.675). Weight change since age 50 was further evaluated among women over age 55. Women who maintained their weight within ±5% since age 50, particularly within a normal range (BMI = 18.5-24.9 kg/m(2) ), or reduced their weight from overweight (BMI = 25-29.9 kg/m(2) ) or obesity (BMI ≥30 kg/m(2) ) to normal range, had a longer mean of current telomere length than women who gained weight since age 50 (Ptrend = 0.025), particularly those who stayed in obesity or gained weight from normal range or overweight to obesity (P = 0.023).

CONCLUSION:

Our findings show that telomere shortening is associated with obesity and that maintaining body weight within a normal range helps maintain telomere length.

PMID:
23408544
PMCID:
PMC3676725
DOI:
10.1002/oby.20321
[Indexed for MEDLINE]
Free PMC Article
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