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Obesity (Silver Spring). 2013 Nov;21(11):2413-9. doi: 10.1002/oby.20316. Epub 2013 May 29.

Genome-wide association study of genetic factors related to confectionery intake: potential roles of the ADIPOQ gene.

Author information

1
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Abstract

OBJECTIVE:

The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted.

DESIGN AND METHODS:

For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10(-5) and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]).

RESULTS:

We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10(-5) for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin.

CONCLUSIONS:

Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

PMID:
23408455
DOI:
10.1002/oby.20316
[Indexed for MEDLINE]
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