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Jpn J Ophthalmol. 2013 May;57(3):294-300. doi: 10.1007/s10384-013-0230-3. Epub 2013 Feb 14.

Choroidal thickness outside the laser irradiation area after photodynamic therapy in polypoidal choroidal vasculopathy.

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1
Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Abstract

PURPOSE:

To evaluate changes in choroidal thickness adjacent to the area of laser application after photodynamic therapy (PDT) in patients with polypoidal choroidal vasculopathy (PCV) using enhanced depth imaging spectral-domain optical coherence tomography.

METHODS:

Masked observers measured the choroidal thickness at the subfovea and superior, inferior and temporal areas adjacent to the area of laser application before, 2 days, 1 week and 1 and 3 months after treatment.

RESULTS:

Thirty-seven patients with PCV treated with PDT with verteporfin were included. The mean subfoveal choroidal thickness decreased significantly (P < 0.001) from 256 ± 115 μm at baseline to 207 ± 111 μm at 3 months; the mean outside choroidal thickness including the superior, inferior and temporal areas decreased significantly (P < 0.001) from 240 ± 92 μm at baseline to 209 ± 86 μm at 3 months.

CONCLUSION:

PDT affected not only the subfoveal choroid, but also the choroid outside the area of laser application in PCV.

PMID:
23408087
DOI:
10.1007/s10384-013-0230-3
[Indexed for MEDLINE]
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