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Avicenna J Med Biotechnol. 2012 Jan;4(1):3-13.

Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA.

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Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.


Cell free DNA (cfDNA) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. Identification of circulating cancer related DNA molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. For this review, study selection and data extraction were performed by the authors. Detection of point mutations, microsatellite alterations, DNA hypermethylations and losses of heterozygosity in circulating cell free DNA have been characterized in esophagus cancer. Application of circulating cell free DNA as a biomarker, provide the best opportunity for constructing non-invasive tests for early detection, prognosis and management of cancer patients, after therapy in many types of cancer.


Biomarkers; Early detection; Esophagus neoplasm; Prognosis


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