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Exp Ther Med. 2013 Feb;5(2):467-470. Epub 2012 Nov 7.

The prognostic value of copeptin for acute intracerebral hemorrhage patients.

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1
Department of Neurology, Affiliated Hospital of Ji Ning Medical University, Jining 272029;

Abstract

The aim of the current study was to examine the prognostic value of copeptin for acute intracerebral hemorrhage (ICH) patients. A total of 120 patients were recruited. The plasma copeptin levels were measured using sandwich immunoassays. The hematoma volume, Glasgow coma scale (GCS) and ICH score were evaluated. The 90-day functional outcomes were measured with the modified Rankin scale (mRS). Copeptin correlated positively with hematoma volume (r=0.61, P=0.000), Hemphill scores (r=0.78, P=0.000) and white blood cell counts (r=0.58, P=0.000), whereas copeptin correlated negatively with GCS scores (r=-0.79, P=0.000). Copeptin levels were also higher in patients with an unfavorable functional outcome at 90 days than in patients with a favorable outcome (4.14±0.87 vs. 3.09±0.30 ng/ml; t=8.001, P=0.00). Monovariate logistic regression analysis results suggest that copeptin is a predictor of the 90-day functional outcomes of ICH patients (OR=3.17, 95% CI 2.01-4.35, P=0.003. Multivariate logistic regression analysis results indicate that copeptin is an independent predictor of the 90-day functional outcomes of ICH patients.

KEYWORDS:

copeptin; intracerebral hemorrhage; prognostic value

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