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Chromosoma. 1990 Apr;99(1):3-10.

Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes.

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Genetics Group, Los Alamos National Laboratory, NM 87545.


The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.

[Indexed for MEDLINE]

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